Difference between revisions of "File:Cannabis comparative risk assessment.pdf"
m (Text replacement - "|typeDraft" to "|draft") |
(image) |
||
(2 intermediate revisions by the same user not shown) | |||
Line 1: | Line 1: | ||
{{Document | {{Document | ||
− | | | + | |title=Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach |
|publication_date=2015/01/30 | |publication_date=2015/01/30 | ||
|type=Report | |type=Report | ||
+ | |image=Cannabis comparative risk assessment.jpg | ||
|description=Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach | |description=Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach | ||
|leaked=No | |leaked=No | ||
Line 8: | Line 9: | ||
|collection=No | |collection=No | ||
|authors=Dirk Lachenmeier, Jürgen Rehm | |authors=Dirk Lachenmeier, Jürgen Rehm | ||
− | |subjects=Cannabis | + | |subjects=Alcohol, Cannabis, MDMA, Heroin, Nicotine, Amphetamines, Benzodiazepines |
− | |constitutes=Scientific report, | + | |constitutes=Scientific report, risk assessment |
|source_name=US National Library of Medicine | |source_name=US National Library of Medicine | ||
|source_URL=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311234/ | |source_URL=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311234/ | ||
Line 18: | Line 19: | ||
A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure (MOE) approach was conducted. The MOE is defined as ratio between toxicological threshold (benchmark dose) and estimated human intake. Median lethal dose values from animal experiments were used to derive the benchmark dose. The human intake was calculated for individual scenarios and population-based scenarios. | A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure (MOE) approach was conducted. The MOE is defined as ratio between toxicological threshold (benchmark dose) and estimated human intake. Median lethal dose values from animal experiments were used to derive the benchmark dose. The human intake was calculated for individual scenarios and population-based scenarios. | ||
− | The MOE was calculated using probabilistic Monte Carlo simulations. The benchmark dose values ranged from 2 mg/kg body weight for heroin to 531 mg/kg body weight for alcohol (ethanol). For individual exposure the four substances alcohol, nicotine, cocaine and heroin fall into the ‘‘high risk’’ category with MOE < 100. On a population scale, only alcohol would fall into the ‘‘high risk’’ category, and cigarette smoking would fall into the ‘‘risk’’ category, while all other agents (opiates, cocaine, amphetamine-type stimulants, ecstasy | + | The MOE was calculated using probabilistic Monte Carlo simulations. The benchmark dose values ranged from 2 mg/kg body weight for [[heroin]] to 531 mg/kg body weight for alcohol (ethanol). For individual exposure the four substances [[alcohol]], [[nicotine]], [[cocaine]] and [[heroin]] fall into the ‘‘high risk’’ category with MOE < 100. On a population scale, only alcohol would fall into the ‘‘high risk’’ category, and cigarette smoking would fall into the ‘‘risk’’ category, while all other agents ([[opiates]], [[cocaine]], [[amphetamine]]-type stimulants, [[ecstasy]] and [[benzodiazepines]]) had MOEs > 10,000. The toxicological MOE approach validates epidemiological and social science-based drug ranking approaches especially in regard to the positions of alcohol and tobacco (high risk) and cannabis (low risk). |
[[Category:Doc]] | [[Category:Doc]] |
Latest revision as of 12:52, 27 June 2016
Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach |
Subjects: Alcohol, Cannabis, MDMA, Heroin, Nicotine, Amphetamines, Benzodiazepines
Example of: Scientific report, risk assessment
Source: US National Library of Medicine (Link)
See Also
- Smoking marijuana is 114 times safer than drinking alcohol – study - RT 24 February 2014
★ Start a Discussion about this document
Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach
A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure (MOE) approach was conducted. The MOE is defined as ratio between toxicological threshold (benchmark dose) and estimated human intake. Median lethal dose values from animal experiments were used to derive the benchmark dose. The human intake was calculated for individual scenarios and population-based scenarios.
The MOE was calculated using probabilistic Monte Carlo simulations. The benchmark dose values ranged from 2 mg/kg body weight for heroin to 531 mg/kg body weight for alcohol (ethanol). For individual exposure the four substances alcohol, nicotine, cocaine and heroin fall into the ‘‘high risk’’ category with MOE < 100. On a population scale, only alcohol would fall into the ‘‘high risk’’ category, and cigarette smoking would fall into the ‘‘risk’’ category, while all other agents (opiates, cocaine, amphetamine-type stimulants, ecstasy and benzodiazepines) had MOEs > 10,000. The toxicological MOE approach validates epidemiological and social science-based drug ranking approaches especially in regard to the positions of alcohol and tobacco (high risk) and cannabis (low risk).
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Dimensions | User | Comment | |
---|---|---|---|---|
current | 17:21, 24 February 2015 | (369 KB) | Peter (talk | contribs) | Category:Doc |
- You cannot overwrite this file.
File usage
There are no pages that use this file.